Isolation of two 1-O-alkyl-sn-glycero-3-phosphocholines from the earthworm, Pheretima asiatica.
نویسندگان
چکیده
منابع مشابه
Glycerophosphocholines of the earthworm, Pheretima asiatica.
The lipid composition of the earthworm, Pheretima asiatica (Annelida), was analyzed. Four glycerophospholipids, together with four known glycosphingolipids, were isolated in pure form. The former four were 1-alkyl 2-acyl glycerophosphocholines possessing a C17:0 and/or C18:1 fatty acid residue. Their structures, including the position and geometry of the double bond, were determined on the base...
متن کاملBiosynthesis of 1-alkyl-sn-glycero-3-phosphate via adenosine triphosphate:1-alkyl-sn-glycerol phosphotransferase.
The pink portion of the rabbit harderian gland was found to be a rich source of ATP: I-alkyl-sn-glycerol phosphotransferase. The enzyme, associated with the microsomal fraction of the gland, exhibits a pH optimum of ‘7.1. ATP and Mg2f are absolute requirements for enzymatic activity; the apparent K,,, for Mg2+ATP is 1.6 mM. Manganese partially substituted for Mgz+, but the measured rate in the ...
متن کاملArchaebacterial lipid models: stable liposomes from 1-alky1-2-phytanyl-sn-glycero-3-phosphocholines.
1-Alky1-2-phytanyl-sn-glycero-3-phosphocholines (HPhyPC: alkyl = n-C16H33; EPhyPC: alkyl = n-C20H41), which are artificial chimeric lipids between archaebacterial and ordinary glycerolipids, are prepared. Upon sonication in aqueous media, the lipids gave rise to stable unilamellar liposomes having diameter of 200-1,000 A and gel-to-liquid crystalline phase transition temperature of -11.1 degree...
متن کاملMetabolic fate of platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and lyso-PAF (1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine) in FRTL5 cells.
The metabolism of platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and lyso-PAF (1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine) was investigated in FRTL5 cells, a normal rat thyroid cell line. FRTL5 cells incorporated [3H]PAF and deacetylated this compound to the corresponding [3H]lyso-PAF which was not accumulated or secreted but converted mainly to alkyl-acyl-ph...
متن کاملOverexpression of phospholipid hydroperoxide glutathione peroxidase modulates acetyl-CoA, 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity.
The synthesis of platelet-activating factor (PAF) by -stimulated RBL-2H3 cells was significantly suppressed by overexpression of phospholipid hydroperoxide glutathione peroxidase (PHGPx). When the cells overexpressing PHGPx (L9 cells) were pretreated with diethyl maleate, which reduces PHGPx activity, PAF synthesis upon stimulation rose to levels seen in mock-transfected cells (S1 cells). Hydro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1992
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.40.1349